Mitochondria as regulators of apoptosis: doubt no more
نویسندگان
چکیده
منابع مشابه
Oncogenes as regulators of apoptosis.
Although cancer is a disease that will afflict one out of three people in the Western world, when considered at a cellular level, it is a rare clonal event. Long-lived organisms, such as humans, have evolved strategies to restrict the development of potentially malignant cells, and one such mechanism is the coupling of proliferative and apoptotic pathways. Multiple oncogenes have the ability to...
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Arachidonic acid (AA) metabolites derived from both cyclooxygenase (COX) and lipoxygenase (LOX) pathways transduce a variety of signals related to cell growth. Here, we report that the AA LOX pathway also functions as a critical regulator of cell survival and apoptosis. Rat Walker 256 (W256) carcinosarcoma cells express 12-LOX and synthesize 12(S)- and 15(S)-hydroxyeicosatetraenoic acids as the...
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Introduction The identification of atoms, anions and cations in protein structure electron density is often inferred from the temperature factor of the atom and from its coordination distances to surrounding amino acids. In many cases unambiguous identification is not possible without the use of additional techniques. Mass spectrometry analysis methods [1] have advanced significantly over the p...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 1998
ISSN: 0005-2728
DOI: 10.1016/s0005-2728(98)00110-8